Z DNA binding protein (ZBP1) Rabbit Polyclonal Antibody

CAT#: TA306502

Rabbit Polyclonal ZBP1 Antibody

Product Images

Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

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  Immunohistochemistry of ZBP1 in human small intestine tissue with ZBP1 antibody at 2.5 ug/ml.

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  Immunofluorescence of ZBP1 in Human Small Intestine tissue with ZBP1 antibody at 20 μgg/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZBP1 antibody was raised against a 18 amino acid peptide from near the carboxy terminus of human ZBP1.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Z-DNA binding protein 1
• Database Link:
  NP_001153889
  Entrez Gene 58203 MouseEntrez Gene 171091 RatEntrez Gene 81030 Human
  UniProt ID Q9H171
• Background: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
• Synonyms: C20orf183; DAI; DLM-1; DLM1

Reference Data

• Protein Pathways: Cytosolic DNA-sensing pathway