GRIK1 Rabbit Polyclonal Antibody
Rabbit Polyclonal Grik1 Antibody
Product Datasheet for 'TA306495'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Grik1 antibody was raised against a 16 amino acid peptide near the center of the human Grik1.|
|Formulation||PBS containing 0.02% sodium azide.|
|Purification||Affinity chromatography purified via peptide column|
|Gene Name||glutamate ionotropic receptor kainate type subunit 1|
|Background||Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik1, also known as glutamate receptor 5, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik1 is expressed in GABAergic interneurons of the hippocampus and are thought to participate in the formation of various subtypes of kainate receptors with Grik2 and KA2. Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation has been associated with psychiatric, neurological and neurodegenerative diseases. Numerous isoforms of Grik1 are known to exist and may be subject to RNA editing within the second transmembrane domain, which is thought to alter the properties of ion flow.|
|Synonyms||EAA3; EEA3; GLR5; GLUR5; GluK1; gluR-5|
|Protein Families||Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane|
|Protein Pathways||Neuroactive ligand-receptor interaction|
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