carabin (TBC1D10C) Rabbit Polyclonal Antibody

CAT#: TA306445

Rabbit Polyclonal Carabin Antibody

Product Images

Western blot analysis of Carabin in Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.

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  Immunohistochemistry of Carabin in human spleen tissue with Carabin antibody at 2.5 ug/ml.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Carabin antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human Carabin.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: TBC1 domain family member 10C
• Database Link:
  NP_940919
  Entrez Gene 108995 MouseEntrez Gene 374403 Human
  UniProt ID Q8IV04
• Background: Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.
• Synonyms: CARABIN; EPI64C