Huntingtin Associated Protein 1(HAP1) Rabbit Polyclonal Antibody

CAT#: TA306425

Rabbit Polyclonal HAP1 Antibody


 Product Datasheet for 'TA306425'

USD 415.00


Availability*
In Stock

Size
    • 100 ug


Product images

Specifications

Product Data
Applications WB, IHC, IF
Recommend Dilution WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen HAP1 antibody was raised against a 19 amino acid peptide from near the center of human HAP1.
Isotype IgG
Formulation PBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column
Gene Name huntingtin-associated protein 1
Background Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening; the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.
Synonyms HAP2|HIP5|HLP|hHLP1
Reference Data
Protein Pathways Huntington's disease
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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