TNFSF18 Rabbit Polyclonal Antibody

CAT#: TA306245

Rabbit Polyclonal GITRL Antibody

Specifications

Product Data

• Applications: ELISA, ICC, WB
• Recommended Dilution: GITRL antibody can be used for the detection of GITRL by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL.
  Antibody validated: Immunocytochemistry in human samples. All other applications and species not yet tested.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: GITRL antibody was raised against purified recombinant human GITR ligand.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: GITRL Antibody is Protein A purified.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: tumor necrosis factor superfamily member 18
• Database Link:
  NP_005083
  Entrez Gene 240873 MouseEntrez Gene 8995 Human
  UniProt ID Q9UNG2
• Background: The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions (2,3). Its ligand GITRL is expressed in endothelial and antigen-presenting cells (4) and can activate NF-kappaB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR (5). Dominant negative forms of NIK and TRAF2 expressed in transfected 293 cells substantially inhibited NF-kappaB activation, suggesting that the GITRL-GITR pathway involves both NIK and TRAF2 (4).
• Synonyms: AITRL; GITRL; hGITRL; TL6

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction