p53 AIP1 (TP53AIP1) Rabbit Polyclonal Antibody

SKU TA306074

Rabbit Polyclonal p53AIP1 Antibody

Product Data

• Application: IF, WB
• Recommended Dilution: WB: 4 - 8 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: p53AIP1 antibody was raised against a 15 amino acid peptide from near the amino terminus of human p53AIP1.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: lot specific
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: tumor protein p53 regulated apoptosis inducing protein 1
• Database Link:
  BAB16421
  Q9HCN2
• Background: The p53 tumor-suppressor protein can induce apoptosis through transcriptional activation of several genes. One such protein p53AIP was initially identified through direct cloning of p53 binding sequences from human genomic DNA. Its expression is inducible by p53 following p53 phosphorylation on Ser-46, and ectopic expression of p53AIP leads to apoptotic cell death. Both the phosphorylation of p53 and the induction of p53AIP were blocked by inhibiting the expression of p53DINP1 by the introduction of antisense oligonucleotides to p53DINP1, suggesting that the apoptosis associated with p53AIP expression is regulated by p53DINP1. Finally, as adenovirus-mediated introduction of p53AIP has been shown to suppress tumor growth in vivo, it has been suggested that p53AIP gene transfer may become a useful strategy for the treatment of p53-resistant cancers. Three isoforms of p53AIP are known to exist; this antibody will detect all three.
• Synonyms: P53AIP1

Reference Data