MRP4 (ABCC4) Goat Polyclonal Antibody

CAT#: TA302970

Goat Polyclonal Antibody against ABCC4

Product Images

TA302970 staining (0.5ug/ml) of rat renal cortex membranes (20ug total protein per lane). Detected by western blot using chemiluminescence. Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald.

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  Figure from citation: Western blot analysis of protein expression of BCRP and four MRP family transporters by using anti-ABCG2, anti-ABCC1, anti-ABCC2, anti-ABCC3 and anti-ABCC4 antibody in HeLa and HeLa1A5 cells. View Citation

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  Figure from citation: Western blot analysis of human BCRP, MRP1, MRP3, MRP7 and UGT1A1 protein expression by using anti-ABCG2, anti-ABCC1, anti-ABCC3, anti-ABCC4 and anti-UGT1A1 antibody in various cell lines. View Citation

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  TA302970 (4ug/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:64,000. WB: 1-3µg/ml. IHC: 2-4µg/ml.
• Reactivities: Human, Rat (Expected from sequence similarity: Mouse)
• Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence CNGQPSTLTIFETAL, from the C Terminus of the protein sequence according to NP_005836.2.
• Formulation: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATP binding cassette subfamily C member 4
• Database Link:
  NP_001098985
  Entrez Gene 170924 RatEntrez Gene 239273 MouseEntrez Gene 10257 Human
  UniProt ID O15439
• Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq]
• Synonyms: MOAT-B; MOATB; MRP4

Reference Data

• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: ABC transporters