Mel18 (PCGF2) Goat Polyclonal Antibody

SKU TA302537

Goat Polyclonal Antibody against MEL18 / PCGF2

Product Data

• Application: WB
• Recommended Dilution: ELISA: 1:16,000. WB: 1-2µg/ml.
• Reactivity: Cow), Human (Expected from sequence similarity: Dog
• Antibody Host: Goat
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Peptide with sequence C-KMTVNGAPVPPLT, from the C Terminus of the protein sequence according to NP_009075.
• Buffer: Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Concentration: lot specific
• Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 41413 Da
• Gene Name: polycomb group ring finger 2
• Database Link:
  NP_009075
  P35227
• Background: The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq]
• Synonyms: MEL-18; RNF110; ZNF144

Reference Data

• Protein Families: Transcription Factors