Caspase 3 (CASP3) Mouse Monoclonal Antibody [Clone ID: CPP32 4-1-18]

CAT#: TA301776

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Mouse Monoclonal Antibody against Caspase 3 (CPP32 4-1-18)



USD 465.00


Availability*
In Stock

Size
    • 200 ul


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Specifications

Product Data
Clone Name CPP32 4-1-18
Applications IHC, WB
Recommended Dilution WB: 1:500-1: 1000
Reactivity Human
Host Mouse
Isotype IgG2a, kappa
Clonality Monoclonal
Immunogen Full-length recombinant human Caspase 3 protein.
Formulation 0.1% sodium azide
Purification Affinity purified
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name caspase 3
Background Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
Synonyms CPP32; CPP32B; SCA-1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protease
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis

Citations (5)

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