Caspase 3 (CASP3) Mouse Monoclonal Antibody [Clone ID: CPP32 4-1-18]

SKU TA301776

Mouse Monoclonal Antibody against Caspase 3 (CPP32 4-1-18)

Product Data

• Clone Name: CPP32 4-1-18
• Application: ICC/IF, IHC, IP, Simple Western, WB
• Recommended Dilution: Immunohistochemistry-Frozen, Western Blot: 1:500-1:1000, Simple Western: 1:2000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry: 1:200-1:500, Immunoprecipitation: 2 ug / mg lysate, Immunocytochemistry/ Immunofluorescence: 2 ug/ml
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG2a, kappa
• Clonality: Monoclonal
• Immunogen: Full-length recombinant human Caspase 3 protein.
• Buffer: 0.1% sodium azide
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: caspase 3
• Database Link:
  NP_116786
  P42574
• Background: Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase-9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
• Synonyms: CPP32; CPP32B; SCA-1

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protease
• Protein Pathways: Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Epithelial cell signaling in Helicobacter pylori infection, Huntington's disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, p53 signaling pathway, Parkinson's disease, Pathways in cancer, Viral myocarditis