HNRPM (HNRNPM) Mouse Monoclonal Antibody [Clone ID: 2A6]

SKU TA301557

Mouse Monoclonal Antibody against Heterogenous Nuclear ribonucleoproteins M3/4 (2A6)

Product Data

• Clone Name: 2A6
• Application: ICC/IF, IHC, IP, Simple Western, WB
• Recommended Dilution: Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen: 1:10-1:500, Simple Western: 1:3000
• Reactivity: Bovine, Human, Mouse, Porcine, Rabbit, Rat
• Antibody Host: Mouse
• Isotype: IgG2b, kappa
• Clonality: Monoclonal
• Immunogen: M19 fusion protein containing full-length human protein.
• Buffer: Ascitic fluid and sodium azide
• Purification: Ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: heterogeneous nuclear ribonucleoprotein M
• Database Link:
  NP_112480
  P52272
• Background: Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
• Synonyms: CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Spliceosome