LKB1 (STK11) Rabbit Polyclonal Antibody

CAT#: TA300047

STK11 Antibody (N-term I29) Rabbit Polyclonal Antibody (Pab)

Product Images

Western blot analysis of STK11 (arrow) using rabbit polyclonal STK11 Antibody

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  STK11 Antibody (I29) (Cat. #TA300047) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the STK11 antibody detected the STK11 protein (arrow).

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  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

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  Confocal immunofluorescent analysis of STK11 (LKB1) Antibody (N-term I29) (Cat#TA300047) with ZR-75-1 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).

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  STK11 (LKB1) Antibody (N-term I29) (Cat. #TA300047) flow cytometric analysis of NCI-H460 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

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Specifications

Product Data

• Applications: FC, IF, IHC, WB
• Recommended Dilution: IHC: 1:50~100, WB: 1:1000, FC: 1:10~50, IF: 1:10~50
• Reactivities: Human (Predicted: Mouse, Rat, Chicken, Xenopus)
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This STK11 (LKB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-44 amino acids from the N-terminal region of human STK11 (LKB1).
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: serine/threonine kinase 11
• Database Link:
  NP_000446
  Entrez Gene 20869 MouseEntrez Gene 314621 RatEntrez Gene 6794 Human
  UniProt ID Q15831
• Background: STK11 encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms.
• Synonyms: hLKB1; LKB1; PJS

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Adipocytokine signaling pathway, mTOR signaling pathway