Mouse Monoclonal Antibody [Clone ID: NF-09]
Mouse Monoclonal anti-Neurofilament M (160 kD) Antibody
Product Datasheet for 'SM3068P'
|Recommend Dilution||IHC, ICC/IF, WB|
|Immunogen||Pellet of Porcine brain cold stable proteins after depolymerization of microtubules|
|Formulation||Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide as preservative.|
|Purification||Affinity Chromatography on Protein A|
|Background||Neurofilaments (NFs) are a type of intermediate filament (IF) expressed almost exclusively in neuronal cells, and in those cells most prominently in large axons, the longest cell protrusions known in vertebrates. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights (NF-H - heavy chain, NF-M - medium chain and NF-L - light chain). The three NF subunits share sequence and structural similarity in a coiled-coil core domain, but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm.|
|The use of this Antibodies has been cited in the following citations:|
Monoclonal antibody NF-09 specific for neurofilament protein NF-M
,Dráberová E, Sulimenko V, Kukharskyy V, Dráber P,
Folia Biol (Praha). 1999
,PubMed ID 10732731
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