Aggrecan (ACAN) Mouse Monoclonal Antibody [Clone ID: HAG7D4 (7D4)]

CAT#: SM1353P

Reviews ()
Write a review

Aggrecan (ACAN) mouse monoclonal antibody, clone HAG7D4 (7D4), Purified



USD 684.00

2 Weeks*

Size
    • 200 ug

Product images

Other products for "ACAN"

Specifications

Product Data
Clone Name HAG7D4 (7D4)
Applications ELISA, IHC, IP, WB
Recommended Dilution ELISA.
Western blot.
Immunoprecipitation.
Immunohistochemistry on Frozen Sections.
Immunohistochemistry on Paraffin Sections
: Requires a standard heat mediated antigen retrieval using a microwave.
Histology Positive Control Tissue: Cerebral Cortex.
Reactivities Bovine, Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified Human articular cartilage Aggrecan.
Specificity This antibody Clone 7D4 Cat.-No SM1353P recognizes Human Aggrecan, a proteoglycan component of cartilage matrix and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS).
Studies also showed a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues (Virgintino et al. 2009 in Ref.1). 
SM1353P recognizes epitopes within the N-terminal G1-IGD-G2 region of Aggrecan, that has been identified as a cluster 1 isoform. 
Negative Species: Chicken, Fish and Rat.
Formulation PBS
State: Purified
State: Liquid purified IgG fraction from Tissue Culture Supernatant
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: One year from despatch.
Gene Name aggrecan
Background Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
Synonyms ACAN, AGC1, CSPG1, MSK16
Reference Data
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.