IL3RA Mouse Monoclonal Antibody [Clone ID: 6H6]

CAT#: SM1190P

IL3RA mouse monoclonal antibody, clone 6H6, Purified

Specifications

Product Data

• Clone Name: 6H6
• Applications: FC, IHC, IP, WB
• Recommended Dilution: Flow Cytometry.
  Immunoprecipitation.
  Western blot.
  Immunohistochemistry on Frozen Sections.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: IL3 receptor alpha chain expressed on the surface of transiently transfected COS cells
• Specificity: This antibody recognizes CD123 (interleukin 3 receptor alpha), a 60-70 kDa transmembrane protein expressed by myeloid precursors, megakaryocytes, macrophages, dendritic cells, mast cells, basophils, and some B cells. This antibody does not inhibit IL-3 binding to its receptor.
• Formulation: Phosphate buffered saline (PBS)
  State: Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 15 mM sodium azide, approx. pH 7.4
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Gene Name: interleukin 3 receptor subunit alpha
• Database Link:
  Entrez Gene 3563 Human
  UniProt ID P26951
• Background: CD123 is the alpha chain of interleukin 3 receptor (IL-3R alpha). This subunit heterodimerizes with the interleukin 3 receptor beta chain (CD131), which is shared with other receptors. CD123 interacts with IL-3 specifically, but with low affinity, and association with the beta subunit confers high affinity binding to the receptor heterodimer. Both chains are required for signaling, but receptor activation and signal transduction depend on IL-3 binding to CD123 as the initial step.
• Synonyms: Interleukin-3 receptor subunit alpha, IL-3R-alpha, IL3 receptor alpha