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FLT4 Mouse Monoclonal Antibody [Clone ID: (3C3) 9D9]

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SKU
DM3512P
FLT4 mouse monoclonal antibody, clone (3C3) 9D9, Aff - Purified
Size:
100 ug
Conjugation:
Unconjugated
  $490.00
2 Weeks*
Bulk/Customize

View other "FLT4 or NP_002011.2" antibodies

Specifications
Specifications
Product Data
Clone Name (3C3) 9D9
Application ELISA, FC, IF, IHC, WB
Recommended Dilution ELISA: 0.5-1.5 µg/ml in direct ELISA, allows detection of 0.25-0.5 ng/well.
FACS: 1-5 µg/ml.
Immunofluorescence/Immunohistochemistry: 1-10 µg/ml.
Western blot 0.5-1 µg/ml, detection limit is approximately 5 ng/lane under reducing conditions.
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant Human Vascular Endothelial Growth Factor Receptor 3 (rh VEGFR-3/FLT-4) extracellular domain.
Specificity Detects Human VEGFR-3/FLT-4.
Other species not tested.
Buffer PBS pH 7.4 without preservatives or stabilizers
State: Aff - Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with sterile water to a concentration of 0.1-1.0 mg/ml
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Gene Name fms related tyrosine kinase 4
Database Link
Background VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk 1) and VEGFR-3 (FLT-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domains and kinase insert domains in their intracellular regions. The expression of VEGFR-1 to -3 is almost exclusively restricted to hematopoietic precursor cells, vascular and lymphatic endothelial cells and to the monocyte/macrophage lineage. These receptors play essential roles in vasculogenesis, hematopoiesis, angiogenesis and lymphangiogenesis. The VEGFR-3 cDNA encodes a 1298 amino acid (aa) residue precursor protein with a 24 aa residue signal peptide. Mature VEGFR-3 is composed of a 751 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 482 aa residue cytoplasmic domain. Both VEGF-C and VEGF-D have been shown to bind and activate VEGF R3 (Flt-4). The Flt-4 gene is widely expressed in the early embryo but becomes restricted to the lymphatic endothelial a latter stage of development. It is important for lymphangiogenesis.
Synonyms VEGFR3, FLT4, VEGF Receptor 3
Reference Data
Protein Categories Cardiovascular diseases, Cytokines, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins, Secreated Proteins
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Documents
Resources

file-alt Citations

Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines
Xu, Hausmann, Dietmaier et al
BMC Cancer (2010) 10, 302 DOI: 10.1186/1471-2407-10-302
Cited by 48
AI Summary: In this study, OriGene products—including specific primers for EGFR, HGFR, IGF1R, IGF2R, and VEGFR1-3—were used to assess the expression of growth factor receptors in cholangiocarcinoma cell lines, enabling the evaluation of receptor presence and the impact of EGFR inhibition.
FigureFigureFigure
Response to a novel multitargeted tyrosine kinase inhibitor pazopanib in metastatic Merkel cell carcinoma
Davids, Charlton, Ng et al
J Clin Oncol (2009) 27 (26), e97-100 DOI: 10.1200/JCO.2009.21.8149
AI Summary: OriGene products contributed to this study by providing the anti-VEGF (TA500823) and anti-VEGFR2 (TA301426) antibodies, which were used for immunohistochemical analysis of tumor samples to assess the expression of angiogenic markers in metastatic Merkel cell carcinoma.
Showing 1-2 of 2 papers.
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