CCL3 Mouse Monoclonal Antibody [Clone ID: 125]

CAT#: DM2043

CCL3 mouse monoclonal antibody, clone 125, Purified

Specifications

Product Data

• Clone Name: 125
• Applications: ELISA, WB
• Recommended Dilution: ELISA, Western blot.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Purified recombinant human MIP-1α
• Specificity: Reactive with recombinant MIP-1α.
  Does not show any cross reaction with other human cytokines or growth factors tested such as M-CSF, GM-CSF, IL-7, IL-8, IL-16, IL-1β, bFGF, TGF-β, EGF, TNF-α and EPO.
• Formulation: 0.01M PBS, pH 7.2
  State: Purified
  State: Lyophilized purified IgG
• Reconstitution Method: Double distillated water is recommended to adjust the final concentration to 1.00 mg/ml
• Purification: Protein G affinity chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody (lyophilized and reconstituted) at -20°C. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: C-C motif chemokine ligand 3
• Database Link:
  Entrez Gene 6348 Human
  UniProt ID P10147
• Background: Macrophage Inflammatory Protein 1 alpha (MIP1 alpha) and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.
• Synonyms: CCL-3, MIP-1-alpha, C-C motif chemokine 3, MIP1A, Small-inducible cytokine A3, SCYA3, LD78 alpha, G0S19-1 protein