CEACAM5 (CEACAM1/5) Mouse Monoclonal Antibody [Clone ID: 4/3/17]
| Product Data | |
| Clone Name | 4/3/17 |
|---|---|
| Application | ELISA, FC, IF, IHC, WB |
| Recommended Dilution | ELISA: 1/200-1/400. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400. Flow Cytometry: 1.2 µg/106 cells. Immunohistochemistry on Cryosections: 1-2 µg/106 cells. |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Immunisation with extracted protein of CEACAM5. |
| Specificity | Recognizes CEACAM1, 5 (BGP, CEA, CD66a/e). |
| Buffer | PBS, pH 7.2 State: Purified State: Liquid purified IgG fraction |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein G |
| Conjugation | Unconjugated |
| Storage | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | carcinoembryonic antigen related cell adhesion molecule 5 |
| Database Link | |
| Background | CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family (1). It consists of seven CEACAM (CEACAM1, CEACAM3-CEACAM8) and 11 pregnancy-specific glycoprotein (PSG1-PSG11) members. The CEA family proteins belong to the immuno-globulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/CEACAM5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker (2). CEACAM1 expression is down-regulated in many tumors indicating a tumor-suppressive function. The anti-tumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (3). The function of CEA family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria (1). |
| Synonyms | Carcinoembryonic antigen, BGP, CEA, CEACAM1, CEACAM5, CD66a,e |
| Reference Data | |
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