GDF15 (N-term) Mouse Monoclonal Antibody [Clone ID: ME-6D10]

SKU DM1224

GDF15 (N-term) mouse monoclonal antibody, clone ME-6D10, Purified

Product Data

• Clone Name: ME-6D10
• Application: ELISA, FC, WB
• Recommended Dilution: Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.; Flow Cytometry: 1.2 µg/10⁶ cells.
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Genetic immunisation with cDNA encoding amino acids 30-194 (N-term) of MIC-1 proprotein.
• Specificity: Recognizes Human Macrophage Inhibitory Cytokine-1 (MIC-1). ; Other species not tested.
• Buffer: Phosphate buffered saline, pH 7.2 without preservatives; State: Purified; State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. ; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: growth differentiation factor 15
• Database Link:
  Q99988
• Background: Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-ß superfamily that regulates a wide variety of physiological processes involved in tissue differentiation and maintenance (1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulphide-linked dimeric protein. Expression of MIC-1 results in inhibition of macrophage activation, regulated by the p53 pathway, in response to pro-inflammatory monokines (1,2). MIC-1 is involved in tumour pathogenesis and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers. It could be a useful marker for aggressive prostate cancer while MIC-1 is upregulated in advanced and more aggressive prostatic tumours (3).
• Synonyms: GDF-15, MIC1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, MIC-1, Prostate differentiation factor, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1

Reference Data

• Protein Families: Druggable Genome, Secreted Protein