FPRL1 (FPR2) Mouse Monoclonal Antibody [Clone ID: GM-1D6]

CAT#: DM1216

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FPRL1 (FPR2) mouse monoclonal antibody, clone GM-1D6, Purified



USD 487.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name GM-1D6
Applications ELISA, FC, IF, WB
Recommended Dilution Flow Cytometry: 1.2 µg/106 cells. 
The antibody is routinely tested by Flow Cytometry on BOSC cells transiently transfected with an FPRL1 expression vector.
Immunofluorescence: 1 µg/106 cells.
Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen GM1D6 was generated by genetic immunisation of BALB/c mice with a proprietary GPCR-immunisation vector containing the FPRL1 cDNA. 
Selection: based on recognition of the complete native protein expressed on transfected mammalian cells.
Specificity GM1D6 recognizes FPRL1 transiently expressed on the cell surface of transfected BOSC cells (Fig.1).
Formulation PBS, pH 7.2
State: Purified
State: Liquid purified IgG fraction
Preservative: None
Concentration lot specific
Purification Affinity Chromatography on Protein G
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Human formyl peptide-receptor-like-1 (FPRL1) belongs to the large family of G-protein coupled receptors (GPCR). It is a seven transmembrane protein expressed on mononuclear phagocytes and microglial cells. FPRL1 is a member of the chemoattractant subfamily of G protein-coupled receptors and plays a key role in inflammation via chemotaxis and the regulation of mediator release from leukocytes. It interacts with formyl peptides to attract phagocytes to sites of infection and promote inflammatory reactions (1). FPRL1 also interacts with amyloid beta peptides and has been implicated in phagocyte attraction to sites of amyloid plaques in Alzheimer’s disease (2). Since FPRL1 is expressed in neutrophils and monocytes, and it was shown using another monoclonal antibody that chemokines can be potent and specific ligands, FPRL1 might have interesting functions in inflammatory pathways (3).
Synonyms N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.