CEACAM1 Mouse Monoclonal Antibody [Clone ID: 8G5]

SKU DM1201

CEACAM1 mouse monoclonal antibody, clone 8G5, Purified

Product Data

• Clone Name: 8G5
• Application: ELISA, FC, IF, IHC
• Recommended Dilution: Flow Cytometry: 1.2 μg/10⁶ cells.; ELISA: 1/200-1/400.; Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.; Immunofluorescence.; Immunohistochemistry on Cryosections: 10 μg/ml.
• Reactivity: Human, Mammalian
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Genetic immunisation with cDNA encoding the extracellular region of Human CEACAM1-A2.; Based on recognition of the complete native protein expressed on transfected mammalian cells.
• Specificity: This antibody recognizes Human CEACAM1 (biliary glycoprotein I, BGP/CD66a).; This antibody detects complete native protein expressed on transfected cells.
• Buffer: PBS, pH 7.2; State: Purified; State: Liquid purified Ig fraction; Preservative: None
• Concentration: lot specific
• Purification: Protein G Chromatography
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: carcinoembryonic antigen related cell adhesion molecule 1
• Database Link:
  P13688
• Background: CEACAM1 (BGP/CD66a) is a transmembrane glycoprotein which belongs to the carcinoembryonic antigen (CEA) gene family (1,2). It is expressed on cells of epithelial and myeloid origin and mediates homophilic intercellular interactions that influence cellular growth, immune cell activation, and tissue morphogenesis. CEACAM1 is a putative tumour suppressor based on diminished expression in some aggressive types of cancer cells (3). The anti-tumour effect may be due to inhibition of tumour angiogenesis, possibly by increased secretion of anti-angiogenic molecules from the cells (4). Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM.
• Synonyms: BGP, BGP1, Biliary glycoprotein 1

Reference Data