P Glycoprotein (ABCB1) Mouse Monoclonal Antibody [Clone ID: OTI11D2]
CAT#: CF806689
Carrier-free (BSA/glycerol-free) ABCB1 mouse monoclonal antibody, clone OTI11D2 (formerly 11D2)
Formulation: Standard
Specifications
Product Data | |
Clone Name | OTI11D2 |
Applications | IHC |
Recommended Dilution | IHC 1:150 |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) produced in SF9 cell. |
Formulation | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | ATP binding cassette subfamily B member 1 |
Database Link | |
Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008] |
Synonyms | ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1 |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | ABC transporters |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Antibody Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TA806689 | ABCB1 mouse monoclonal antibody, clone OTI11D2 (formerly 11D2) |
USD 447.00 |
|
TA806689AM | ABCB1 mouse monoclonal antibody, clone OTI11D2 (formerly 11D2), Biotinylated |
USD 509.00 |
|
TA806689BM | ABCB1 mouse monoclonal antibody, clone OTI11D2 (formerly 11D2), HRP conjugated |
USD 509.00 |
|
TA806689S | ABCB1 mouse monoclonal antibody, clone OTI11D2 (formerly 11D2) |
USD 200.00 |
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