Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (aa 493-502) Rabbit Polyclonal Antibody

CAT#: BP2143

Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) (aa 493-502) rabbit polyclonal antibody, Serum

Specifications

Product Data

• Applications: ELISA, IF, IHC, WB
• Recommended Dilution: Has been characterized by Western blotting, ELISA, and cell staining techniques.
  Suitable for immunocytochemical (ABC techniques, 1/400 dilution) and western immunoblotting (tissue homogenates, 1/800 dilution, single band at 63 kDa) detection of the receptor.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Peptide analogue of the carboxyl terminal (aa 493-502) of the human nicotinic alpha 7 receptor attached to a carrier protein.
• Specificity: Specific for the COOH terminal of nicotinic alpha 7 receptor.
  Cross-reactivity:
  Nicotinic alpha 7 receptor (493-502): 100%
  Nicotinic alpha 7 receptor: ~85%
  No Cross-reactivity with Nicotinic alpha 3 receptor, Nicotinic alpha 4 receptor, Nicotinic alpha 5 receptor, Nicotinic beta 2 receptor, Nicotinic beta 3 receptor and Nicotinic beta 4 receptor.
• Formulation: State: Serum
  State: Lyophilized neat serum
  Preservative: None
• Reconstitution Method: Restore with 0.1 ml PBS containing 10 mg/ml BSA or with additional buffer for more dilute antisera.
• Conjugation: Unconjugated
• Storage: Lyophilized: Store at 2-8°C (preferably in a dessicator).
  Reconstituted: Aliquot and store at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: cholinergic receptor nicotinic alpha 7 subunit
• Database Link:
  Entrez Gene 1139 Human
  UniProt ID P36544
• Background: Nicotinic acetylcholine receptors (nAChRs), are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. Following acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
• Synonyms: Nicotinic acetylcholine receptor subunit alpha-7, CHRNA7, NACHRA7