Vaccinia Virus (Lister Strain) Rabbit Polyclonal Antibody

CAT#: BP1076

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Vaccinia Virus (Lister Strain) rabbit polyclonal antibody, Purified

Conjugation: Unconjugated Biotin FITC



USD 690.00

In Stock*

Size
    • 1 ml

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Specifications

Product Data
Applications ELISA, IHC
Recommended Dilution ELISA.
Immunohistochemistry (Protein K digestion is recommended with Formalin-Fixed Paraffin Embedded Sections).
Reactivities Vaccinia virus
Host Rabbit
Clonality Polyclonal
Immunogen Lister Strain (mixture of virions and infected cell polypeptides)
Specificity Recognizes purified virions.
Does not cross-react with Parainfluenza (1-3), RSV, Adenovirus, Influenza A & B or HSV-1.
Does not react with uninfected cells.
Reactive with Lister, Wyeth, New York City and MVA strains of Vaccinia.
Formulation 0.01M PBS, pH 7.2
State: Purified
State: Liquid purified Ig fraction (> 95% pure)
Stabilizer: None
Preservative: 0.09% Sodium Azide
Concentration 4-5 mg/ml (OD280 nm, E0.1% = 1.4)
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Vaccinia virus is an Orthopoxvirus, containing double stranded DNA. Fusion protein plays an important role in the entry of enveloped virus into cells. As vaccinia virus has a wide host range, it is conceivable that certain cellular components that are ubiquitously expressed on the cell mediate virus infection. The study of the entry process, attachment, fusion and the proteins and receptors involved is complex. During vaccinia virus infection, the fusion process is attributed to the action of the 14KDa protein (A27L). The N terminus of this protein recognises heparan sulfate on the cell surface. It interacts with the negative charges of sulfates of glycosaminoglycans (GAGs). Therefore, antibodies that recognize this 14KDa protein are able to neutralize vaccinia virus infection and enable identification other viral and cellular proteins which participate in the vaccinia virus entry process.
Reference Data
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