LRPAP1 Mouse Monoclonal Antibody [Clone ID: 7F1]
LRPAP1 mouse monoclonal antibody, clone 7F1, Purified
|Applications||IF, IHC, WB|
|Specificity||This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor).
It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
|Formulation||PBS buffer, pH 7.4 containing 0.5% BSA as stabilizer.
State: Lyophilized purified IgG fraction.
|Reconstitution Method||Restore in 1 ml distilled water.|
|Purification||Affinity Chromatography on Protein A .|
|Storage||Prior to reconstitution store at 2-8°C.
Following reconstitution store the antibody at -20°C.
Avoid repeated freezing and thawing.
|Stability||Shelf life: one year from despatch.|
|Background||Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.|
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