LRPAP1 Mouse Monoclonal Antibody [Clone ID: 7F1]

CAT#: BM5054

LRPAP1 mouse monoclonal antibody, clone 7F1, Purified

Specifications

Product Data

• Clone Name: 7F1
• Applications: IF, IHC, WB
• Recommended Dilution: Immunoblotting.
  Immunofluorescence.
  Immunohistochemistry: 1/20.
  Ligand-binding assays.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human RAP.
• Specificity: This antibody BM5054 (7F1) reacts with the 39 kDa RAP protein, which is cosynthesized with Human LRP/alpha2MR (low density lipoprotein receptor-related protein/alpha2-Macro-Globulin Receptor).
  It inhibits the binding of ligands, e.g. tPA, uPA, VLDL, liproprotein lipase, and alpha2-Macroglobulin-proteinase complexes to LRP/A2MR.
• Formulation: PBS buffer, pH 7.4 containing 0.5% BSA as stabilizer.
  State: Purified
  State: Lyophilized purified IgG fraction.
• Reconstitution Method: Restore in 1 ml distilled water.
• Purification: Affinity Chromatography on Protein A .
• Conjugation: Unconjugated
• Storage: Prior to reconstitution store at 2-8°C.
  Following reconstitution store the antibody at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: LDL receptor related protein associated protein 1
• Database Link:
  Entrez Gene 4043 Human
  UniProt ID P30533
• Background: Low density lipoprotein receptor-related protein-associated protein 1 (RAP) interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. It is present on the cell surface forming a complex with the alpha 2 macroglobulin receptor heavy and light chains. Binds LRP1B; binding is followed by internalization and degradation. In complex with the alpha 2 MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
• Synonyms: Alpha-2-MRAP, RAP