CACNB3 Rabbit Polyclonal Antibody

CAT#: AP55385PU-N

CACNB3 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/500-1/5000.
  Immunohistochemistry: 1/100-1/500.

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from CAB3 protein
• Specificity: Reacts with Human 54 kDa protein.
• Formulation: 0.1M Tris, 0.1M Glycine and 2% Sucrose
  State: Purified
  State: Lyophilized purified antibody
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: calcium voltage-gated channel auxiliary subunit beta 3
• Database Link:
  Entrez Gene 784 Human
  UniProt ID P54284
• Background: Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omega-agatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca²⁺ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3.
• Synonyms: CAB3, CACNLB3