TRIB3 Rabbit Polyclonal Antibody
| Product Data | |
| Application | ELISA, IHC, WB |
|---|---|
| Recommended Dilution | ELISA. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide derived from N-terminal domain of Human TRIB-3 |
| Specificity | Reacts with Human 39 kDa TRIB-3 protein. |
| Buffer | 0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified antibody Preservative: None |
| Reconstitution Method | Restore in distilled water. |
| Concentration | lot specific |
| Purification | Affinity Chromatography on Protein A |
| Conjugation | Unconjugated |
| Shipping | Ambient |
| Gene Name | tribbles pseudokinase 3 |
| Database Link | |
| Background | A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia. |
| Synonyms | Tribbles homolog 3, TRB3, TRB-3, NIPK, SKIP3 |
| Reference Data | |
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