TRIB3 Rabbit Polyclonal Antibody

CAT#: AP55357PU-N

TRIB3 rabbit polyclonal antibody, Purified

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution:

  ELISA.
  Western Blot: 1/500-1/2000.
  Immunohistochemistry: 1/50-1/500.

• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide derived from N-terminal domain of Human TRIB-3
• Specificity: Reacts with Human 39 kDa TRIB-3 protein.
• Formulation: 0.1M Tris, 0.1M Glycine and 2% Sucrose
  State: Purified
  State: Lyophilized purified antibody
  Preservative: None
• Reconstitution Method: Restore in distilled water.
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Gene Name: tribbles pseudokinase 3
• Database Link:
  Entrez Gene 57761 Human
  UniProt ID Q96RU7
• Background: A novel inhibitor of cell division, Tribbles, blocks mitosis at a critical point in Drosophila morphogenesis. Recently, mammalian homologues of Tribbles (Trbs) have been identified that control mitogen-activated protein kinase (MAPK) activity. TRIB3 also known as TRB-3, SINK, and SKIP3 is a member of Trbs family. Overexpression of this protein inhibits NF-kB-dependent transcription induced by tumor necrosis factor (TNF) stimulation or its downstream signaling proteins but does not inhibit NF-kB translocation to the nucleus and binding to DNA. TRIB3/SKIP3 is also overexpressed in multiple human tumors and is regulated by hypoxia.
• Synonyms: Tribbles homolog 3, TRB3, TRB-3, NIPK, SKIP3