Xanthine Oxidase (XDH) (N-term) Rabbit Polyclonal Antibody

CAT#: AP54582PU-N

Xanthine Oxidase (XDH) (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of XDH Antibody (N-term) in mouse lung tissue lysates (35 ug/lane). XDH (arrow) was detected using the purified Pab.

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  Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with XDH Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1:1;000.
  Western blot: 1:100~500.
  Immunohistochemistry on paraffin sections: 1:50~100.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 213~242 amino acids from the N-terminal region of human XDH
• Specificity: This antibody detects Xanthine dehydrogenase/oxidase (N-term).
• Formulation: PBS with 0.09% (W/V) sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: xanthine dehydrogenase
• Database Link:
  Entrez Gene 22436 MouseEntrez Gene 7498 Human
  UniProt ID P47989
• Background: XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
• Synonyms: Xanthine dehydrogenase/oxidase
• Note: Molecular Weight: 146424 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Caffeine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism