SGPL1 (N-term) Rabbit Polyclonal Antibody

CAT#: AP53891PU-N

SGPL1 (N-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis using SGPL1 Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the SGPL1 antibody detected the SGPL1 protein (arrow).

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  Immunohistochemistry analysis in Formalin Fixed, Paraffin Embedded Human liver tissue stained with SGPL1 Antibody (N-term) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of SGPL1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western blotting: 1/1000.
  Immunohistochemistry: 1/10-1/50.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of Human SGPL1.
• Specificity: Recognizes SGPL1 (N-term).
• Formulation: PBS with 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column followed by peptide Affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: sphingosine-1-phosphate lyase 1
• Database Link:
  Entrez Gene 8879 Human
  UniProt ID O95470
• Background: SGPL1 cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.
• Synonyms: SP-lyase 1, SPL 1, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, KIAA1252
• Note: Molecular Weight: 63524 Da

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Sphingolipid metabolism