PSMB10 (C-term) Rabbit Polyclonal Antibody

SKU AP53486PU-N

PSMB10 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: WB
• Recommended Dilution: ELISA: 1/1000. ; Western Blot: 1/100-1/500.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 213-242 amino acids from the C-terminal region of Human PSMB10
• Specificity: This antibody recognizes Human PSMB10 (C-term).
• Buffer: PBS containing 0.09% (W/V) Sodium Azide as preservative; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: proteasome subunit beta 10
• Database Link:
  P40306
• Background: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.
• Synonyms: PSMB10, MECL1, Proteasome subunit beta type-10, EC=3.4.25.1, Proteasome subunit beta-2i, Proteasome MECl-1, Macropain subunit MECl-1
• Note: Molecular Weight: 28936 Da

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Proteasome