PCDHAC2 (Center) Rabbit Polyclonal Antibody

SKU AP53204PU-N

PCDHAC2 (Center) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: This antibody is suitable for immunohistochemistry on paraffin sections, immunofluorescence and Western blotting.; The suggested dilution is:; Immunofluorescence: 1/10-1/50. ; Immunohistochemistry on paraffin sections: 1/10-1/50.; Western blotting: 1/100-1/500.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 623-652aa) of human PCDHAC2.
• Specificity: This antibody detects human PCDHAC2.
• Buffer: PBS with 0.09% (W/V) Sodium Azide.; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column; followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: protocadherin alpha subfamily C, 2
• Database Link:
  Q9Y5I4
• Background: The PCDHAC2 gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
• Synonyms: Protocadherin alpha-C2, PCDH-alpha-C2
• Note: Molecular Weight: 109450 Da

Reference Data

• Protein Families: Transmembrane