GPCR MRGX2 (MRGPRX2) (C-term) Rabbit Polyclonal Antibody

SKU AP52746PU-N

GPCR MRGX2 (MRGPRX2) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: WB
• Recommended Dilution: Western blot: 1/100-1/500.; Enzyme immunoassay: 1/1000.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 286-316aa) of human MRGPRX2.
• Specificity: This antibody recognizes MRGPRX2 at C-term.
• Buffer: PBS with 0.09% (W/V) Sodium azide; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a Protein A column followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: MAS related GPR family member X2
• Database Link:
  Q96LB1
• Background: MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.
• Synonyms: MRGX2
• Note: Molecular Weight: 37099 Da

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane