LOXL3 (C-term) Rabbit Polyclonal Antibody

CAT#: AP52515PU-N

LOXL3 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of LOXL3 Antibody (C-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the LOXL3 antibody detected the LOXL3 protein (arrow).

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  Immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue reacted with LOXL3 Antibody (C-term) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution:

  ELISA: 1/1000.
  Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/10-1/50.

• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 715-744 amino acids from the C-terminal region of human LOXL3
• Specificity: This antibody recognizes Human LOXL3 (C-term).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: lysyl oxidase like 3
• Database Link:
  Entrez Gene 84695 Human
  UniProt ID P58215
• Background: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.
• Synonyms: LOXL, Lysyl oxidase homolog 3, Lysyl oxidase-like protein 3

Reference Data

• Protein Families: Druggable Genome