IL12RB2 (C-term) Rabbit Polyclonal Antibody

SKU AP52184PU-N

IL12RB2 (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: FC, IHC, WB
• Recommended Dilution:

  This antibody is suitable for flow cytometry, immunohistochemistry on paraffin sections and Western blotting.; The suggested dilution is: ; Flow cytometry: 1/10-1/50. ; Immunohistochemistry on paraffin sections: 1/50-1/100.; Western blotting: 1/100-1/500.

• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 759-788aa) of human IL12RB2.
• Specificity: This antibody detects human IL12RB2 at C-term.
• Buffer: PBS with 0.09% (W/V) Sodium Azide.; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Purified through a protein A column; followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Gene Name: interleukin 12 receptor subunit beta 2
• Database Link:
  Q99665
• Background: The protein encoded by the IL12RB2 gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense.
• Synonyms: IL-12 receptor beta-2, IL-12R-beta-2
• Note: Molecular Weight: 97135 Da

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway