Factor XI (F11) (Center) Rabbit Polyclonal Antibody

CAT#: AP51492PU-N

Factor XI (F11) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of F11 Antibody (Center) in Jurkat cell line lysates (35ug/lane).This demonstrates the F11 antibody detected the F11 protein (arrow).

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  Formalin fixed and paraffin embedded human liver tissue stained with F11 Antibody (Center) followed by peroxidase conjugation of the secondary antibody and DAB staining.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western Blot: 1/1000.
  Immunohistochemistry on Paraffin Sections: 1/50-1/100.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.
• Specificity: This antibody recognizes Human Coagulation factor XI (F11) (Center).
• Formulation: PBS containing 0.09% (W/V) Sodium Azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein A, followed by peptide affinity purification.
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: coagulation factor XI
• Database Link:
  Entrez Gene 2160 Human
  UniProt ID P03951
• Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq].
• Synonyms: Plasma thromboplastin antecedent, PTA, FX1
• Note: Molecular Weight: 70109 Da

Reference Data

• Protein Families: Druggable Genome, Protease, Secreted Protein
• Protein Pathways: Complement and coagulation cascades