Claudin 22 (CLDN22) (Center) Rabbit Polyclonal Antibody

CAT#: AP50947PU-N

Claudin 22 (CLDN22) (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

CLDN22 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CLDN22 antibody detected the CLDN22 protein (arrow).

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  CLDN22 Antibody (Center) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the CLDN22 antibody detected the CLDN22 protein (arrow).

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  CLDN22 Antibody (Center) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Specifications

Product Data

• Applications: FC, WB
• Recommended Dilution: ELISA: 1/1000.
  Western blot: 1/100-1/500.
  Flow Cytometry: 1/10-1/50.
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 97-126 amino acids from the Central region of human CLDN22
• Specificity: This antibody recognizes CLDN22 (Center).
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Preservative: 0.09% (W/V) Sodium Azide
• Concentration: lot specific
• Purification: Protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: 24509 Da
• Gene Name: claudin 22
• Database Link:
  Entrez Gene 53842 Human
  UniProt ID Q8N7P3
• Background: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand.
• Synonyms: Claudin-22

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction