Caspase 12 (CASP12) (Center) Rabbit Polyclonal Antibody

SKU AP50732PU-N

Caspase 12 (CASP12) (Center) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: FC, IF, IHC, WB
• Recommended Dilution: ELISA: 1/1000.; Western blot: 1/100 - 1/500.; Immunohistochemistry on paraffin sections: 1/10 - 1/50.; Flow Cytometry: 1/10 - 1/50.; Immunofluorescence: 1/10 - 1/50.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 172-201 amino acids from the Central region of human CASP12
• Specificity: This antibody reacts to CASP12.
• Buffer: PBS; State: Aff - Purified; State: Liquid purified Ig fraction; Preservative: 0.09% (W/V) sodium azide
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Predicted Protein Size: 38907 Da
• Gene Name: caspase 12 (gene/pseudogene)
• Database Link:
  Q6UXS9
• Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.
• Synonyms: CASP-12, CASP12

Reference Data