C4BPB (Center) Rabbit Polyclonal Antibody

CAT#: AP50624PU-N

C4BPB (Center) rabbit polyclonal antibody, Aff - Purified

Product Images

C4BPB Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C4BPB antibody detected the C4BPB protein (arrow).

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  Western blot analysis of C4BPB (arrow) using rabbit polyclonal C4BPB Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the C4BPB gene.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: ELISA: 1/1000.
  Western blotting: 1/100 - 1/500.
• Reactivities: Human
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 124-153 amino acids from the Central region of human C4BPB
• Specificity: This antibody reacts to C4b-binding protein beta.
• Formulation: PBS containing 0.09% (W/V) sodium azide as preservative
  State: Aff - Purified
  State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: complement component 4 binding protein beta
• Database Link:
  Entrez Gene 725 Human
  UniProt ID P20851
• Background: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.
• Synonyms: C4BPB
• Note: Molecular Weight: 28357 Da