Twinkle (TWNK) (C-term) Rabbit Polyclonal Antibody

SKU AP50418PU-N

Twinkle (TWNK) (C-term) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1/1000.; Western blotting: 1/100 - 1/500.; Immunohistochemistry on paraffin sections: 1/10 - 1/50.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: KLH conjugated synthetic peptide between 663-684 amino acids from the C-terminal region of human C10orf2
• Specificity: This antibody reacts to PEO1.
• Buffer: PBS containing 0.09% (W/V) sodium azide as preservative; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Affinity chromatography on Protein A
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: chromosome 10 open reading frame 2
• Database Link:
  Q96RR1
• Background: This gene encodes a hexameric DNA helicase which unwinds short stretches of double-stranded DNA in the 5' to 3' direction and, along with mitochondrial single-stranded DNA binding protein and mtDNA polymerase gamma, is thought to play a key role in mtDNA replication. The protein localizes to the mitochondrial matrix and mitochondrial nucleoids. Mutations in this gene cause infantile onset spinocerebellar ataxia (IOSCA) and progressive external ophthalmoplegia (PEO) and are also associated with several mitochondrial depletion syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
• Synonyms: C10orf2
• Note: Molecular Weight: 77154 Da

Reference Data

• Protein Families: Druggable Genome