Aspartate beta hydroxylase (ASPH) (Center) Rabbit Polyclonal Antibody

CAT#: AP50276PU-N

Aspartate beta hydroxylase (ASPH) (Center) rabbit polyclonal antibody, Aff - Purified


USD 560.00

2 Weeks*

Size
    • 400 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution ELISA: 1/1000.
Western blotting: 1/100 - 1/500.
Immunohistochemistry on paraffin sections: 1/10 - 1/50.
Reactivities Human
Host Rabbit
Isotype Ig
Clonality Polyclonal
Immunogen KLH conjugated synthetic peptide between 301-331 amino acids from the Central region of human ASPH
Specificity This antibody reacts to ASPH.
Formulation PBS containing 0.09% (W/V) sodium azide as preservative
State: Aff - Purified
State: Liquid purified Ig fraction
Concentration lot specific
Purification Affinity chromatography on Protein A
Conjugation Unconjugated
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens aspartate beta-hydroxylase (ASPH), transcript variant 6
Background This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.
Synonyms ASP beta-hydroxylase, HAAH, JCTN, junctin
Note Molecular Weight: 85863 Da
Reference Data
Protein Families Druggable Genome, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.