ARMETL1 (CDNF) Rabbit Polyclonal Antibody

SKU AP33452PU-N

ARMETL1 (CDNF) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IF, IHC, WB
• Recommended Dilution: ELISA: 1/5000-1/10000. ; Western Blot: 1/5000-1/10000. ; Immunofluorescence: 1/500-1/3000.; Immunohistochemistry on Paraffin Sections: 1/100-1/200. ; Formalin-fixed, paraffin-embedded tissues requires antigen retrieval.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant Human CDNF produced using CHO-based. ; Antigen is purified from cell culture supernatant.
• Specificity: Recognizes Human and Mouse CDNF. Other species not tested.
• Buffer: 50% Saturated Ammonium Sulphate in PBS pH 7.4; State: Aff - Purified; State: Liquid purified IgG fraction
• Concentration: lot specific
• Purification: Affinity Chromatography on Protein G
• Conjugation: Unconjugated
• Storage: Upon receipt, store at 2-8°C.; As product is (NH₄)₂SO₄ precipitate, mix well by pipetting or vortexing prior use.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: cerebral dopamine neurotrophic factor
• Database Link:
  Q49AH0
• Background: CDNF is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007; Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinson’s disease. When administered after 6-OHDA or MPTP –lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.
• Synonyms: ARMET-like protein 1, ARMETL1

Reference Data