B7H4 (VTCN1) (153-165) Goat Polyclonal Antibody

SKU AP31843PU-N

B7H4 (VTCN1) (153-165) goat polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, WB
• Recommended Dilution: Peptide ELISA: 1/16000 (Detection Limit).; Western blot: 0.1-0.3 µg/ml. Approx 28kDa band observed in Human Spleen lysates.
• Reactivity: Bovine, Canine, Human, Mouse, Rat
• Antibody Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_078902.2.
• Specificity: This antibody recognizes VTCN1 (153-165).
• Buffer: Tris buffered saline, pH~7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer; State: Aff - Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: V-set domain containing T cell activation inhibitor 1
• Database Link:
  Q7Z7D3
• Background: B7-H4 is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response.; B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC).
• Synonyms: B7-H4, B7x, B7h.5, B7S1, UNQ659/PRO1291
• Note: Calculated Molecular Weight: 30.9kDa (NP_078902.2).

Reference Data