Amyloid Fibrils (OC) Rabbit Polyclonal Antibody

SKU AP31731PU-N

Amyloid Fibrils (OC) rabbit polyclonal antibody, Purified

Product Data

• Application: ELISA, IF, IHC, IP, WB
• Recommended Dilution: Dot Blot: 1/1000.; A 1/1000 dilution of AP31731PU-N was sufficient for detection of Amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody.; Cited Applications: ; ELISA, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry and Western Blot, Dot Blot.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fibrils prepared from Human Aß42 peptide.
• Specificity: This antibody recognizes generic epitopes common to many Amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins.
• Buffer: PBS; State: Purified; State: Liquid purified IgG fraction; Stabilizer: 50% Glycerol; Preservative: 0.09% Sodium Azide
• Concentration: lot specific
• Purification: Protein A Chromatography
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Shipping: Blue Ice
• Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
• Synonyms: OC, Fibrils

Reference Data