DARC (ACKR1) (1-50) Rabbit Polyclonal Antibody

SKU AP31626PU-N

DARC (ACKR1) (1-50) rabbit polyclonal antibody, Aff - Purified

Product Data

• Application: ELISA, IF, IHC
• Recommended Dilution: ELISA: 1/40000.; Immunofluorescence: 1/100 - 1/500.; Immunohistochemistry on Paraffin Sections: 1/200.
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from human DARC (aa 1-50)
• Specificity: This antibody detects endogenous levels of total CD234 protein.
• Buffer: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02% Sodium Azide and 50% Glycerol; State: Aff - Purified; State: Liquid purified Ig fraction
• Purification: Immunoaffinity Chromatography
• Conjugation: Unconjugated
• Storage: Store the antibody (in aliquots) at -20°C or lower.; Avoid freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: atypical chemokine receptor 1 (Duffy blood group)
• Database Link:
  Q16570
• Background: Duffy blood group antigens, part of the Chemokine Receptor family, appear to be multimeric erythrocyte-membrane protein receptors composed of different subunits. A glycoprotein, GPD, is the major subunit of the protein complex. Other components include the Rh, PGM1, Fy, and PEPC proteins. Duffy antigen is expressed by red blood cells, by postcapillary venule endothelium throughout the body, except in the liver, and by Purkinje cells of the cerebellum. Duffy negativity (lack of Duffy expression in bone marrow) has been linked to protection against malaria. In erythrocytes, the chemokines interleukin-8 and melanoma growth stimulatory activity (MGSA) activate Duffy antigen.
• Synonyms: Duffy antigen/chemokine receptor, Fy glycoprotein, GpFy, Glycoprotein D, FY, GPD

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane