PDCD10 Rabbit Polyclonal Antibody

CAT#: AP26023PU-N

Reviews ()
Write a review

PDCD10 rabbit polyclonal antibody, Aff - Purified



Get 29% off western blot control. View details.

USD 275.00


Availability*
2 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IF, WB
Recommended Dilution Western Blot: 1-5 μg/ml.
Immunofluorescence: 2-10 µg/ml.
Immunohistochemistry.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Highly pure (> 95%) recombinant Human CCM3, amino acids Met1-Ala212 derived from E.coli (Cat.-No AR26004PU-N)
Specificity This antibody will detect recombinant Human CCM-3 in Western Blot and native CCM-3 in Immunohistochemistry.
Formulation 5mM PBS, pH 7.2 without preservatives or stabilizers
State: Aff - Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with sterile water to a concentration of 1.0 mg/ml.
Purification Affinity Chromatography with Immobilized Protein A
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens programmed cell death 10 (PDCD10), transcript variant 1
Background Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Mutations in CCM1, CCM2, or CCM3 lead to cerebral cavernous malformations, one of the most common hereditary vascular diseases of the brain. Endothelial cells within these lesions are the main disease compartments. Here, we show that adenoviral CCM3 expression inhibits endothelial cell migration, proliferation, and tube formation while down regulation of endogenous CCM3 results in increased formation of tube-like structures. Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death. Tyrosine kinase activity profiling suggests that CCM3 supports PDPK-1/Akt-mediated endothelial cell quiescence and survival (Schleider et al, Neurogenetics 12, 2011). 
The CCM-3 is fused to a N-terminal His-tag (6x His).
Synonyms CCM3, TFAR15
Reference Data
Protein Families Druggable Genome
Other products for "PDCD10"
Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies