Cytochrome P450 26B (CYP26B1) (160-396) Rabbit Polyclonal Antibody
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to a region within amino acids 160 and 396 of Human Cytochrome P450 26B |
| Specificity | This antibody recognizes CYP26B1 at aa160-396. |
| Buffer | 0.1M Tris-glycine, pH 7, 20% Glycerol and 0.01% Thimerosal State: Aff - Purified State: Liquid purified IgG fraction |
| Concentration | lot specific |
| Purification | Immunoaffinity Chromatography |
| Conjugation | Unconjugated |
| Storage | Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Gene Name | cytochrome P450 family 26 subfamily B member 1 |
| Database Link | |
| Background | Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Esential for postnatal survival. |
| Synonyms | CYP26A2, Cytochrome P450RAI2, Cytochrome P450 26B1, Cytochrome P450 26A2 |
| Reference Data | |
| Protein Families | Druggable Genome, P450 |
| Protein Pathways | Retinol metabolism |
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