ITPR2 (1152-1164) Goat Polyclonal Antibody

CAT#: AP22536PU-N

ITPR2 (1152-1164) goat polyclonal antibody, Aff - Purified

Product Images

Human Heart (formalin-fixed, paraffin-embedded) stained with ITPR2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Skin (formalin-fixed, paraffin-embedded) stained with ITPR2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Kidney (formalin-fixed, paraffin-embedded) stained with ITPR2 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA: 1/128000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
• Reactivities: Canine, Human, Mouse, Rat, Monkey
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from an internal region of human ITPR2
• Specificity: This antibody detects IP3 receptor 2 / ITPR2 (Internal).
• Formulation: Tris saline buffer, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: inositol 1,4,5-trisphosphate receptor type 2
• Database Link:
  Entrez Gene 16439 MouseEntrez Gene 81678 RatEntrez Gene 3709 Human
  UniProt ID Q14571
• Background: ITPR2 / IP3 Receptor Type 2 belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling.
• Synonyms: Type 2 InsP3 receptor, IP3R2

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease, Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Long-term potentiation, Oocyte meiosis, Phosphatidylinositol signaling system, Vascular smooth muscle contraction