LIS1 (PAFAH1B1) (397-410) Goat Polyclonal Antibody

CAT#: AP22516PU-N

LIS1 (PAFAH1B1) (397-410) goat polyclonal antibody, Aff - Purified

Product Images

Human Pancreas (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Thyroid (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with PAFAH1B1 antibody at 3.75 ug/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Applications: ELISA, IHC, WB
• Recommended Dilution: ELISA: 1/32000.
  Immunohistochemistry on Paraffin Sections: 3.75 µg/ml.
  Western Blot: 1 - 3 µg/ml.
• Reactivities: Bovine, Canine, Human, Mouse, Porcine, Rat, Bat, Chicken, Equine, Hamster, Monkey, Rabbit, Xenopus, Zebrafish
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Peptide from (C-term) of the protein sequence according to NP_000421
• Specificity: This antibody detects PAFAH1B1 / LIS1 at aa 397-410.
• Formulation: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
  State: Aff - Purified
  State: Liquid Ig fracttion
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Conjugation: Unconjugated
• Storage: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: platelet activating factor acetylhydrolase 1b regulatory subunit 1
• Database Link:
  Entrez Gene 18472 MouseEntrez Gene 83572 RatEntrez Gene 5048 Human
  UniProt ID P43034
• Background: PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum.
• Synonyms: PAF-AH alpha, PAFAH alpha, PAFAHA, Lissencephaly-1 protein, LIS-1, MDCR, MDS

Reference Data

• Protein Pathways: Ether lipid metabolism, Metabolic pathways