anoctamin 5 (ANO5) (C-term) Rabbit Polyclonal Antibody

SKU AP21362PU-N

anoctamin 5 (ANO5) (C-term) rabbit polyclonal antibody, Purified

Product Data

• Application: WB
• Recommended Dilution: ELISA: 1/1,000.; Western blotting: 1/100-1/500.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: Synthetic peptide -KLH conjugated between 798~828 amino acids from the C-terminal region of Human ANO5.
• Specificity: Recognizes ANO5 (C-term).
• Buffer: PBS with 0.09% (W/V) Sodium Azide as preservative; State: Purified; State: Liquid purified Ig fraction
• Concentration: lot specific
• Purification: Protein A Chromatography followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.; Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Gene Name: anoctamin 5
• Database Link:
  Q75V66
• Background: ANO5 is a member of the anoctamin family of transmembrane proteins. This protein is likely a calcium activated chloride channel.; Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD), also known as osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity.
• Synonyms: GDD1, TMEM16E, Gnathodiaphyseal dysplasia 1 protein, Transmembrane protein 16E
• Note: Calculated Molecular Weight: 107188 Da

Reference Data

• Protein Families: Transmembrane