CD3D Rabbit Polyclonal Antibody

CAT#: AP20661PU-N

CD3D rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot (WB) analysis of CD3-δ antibody (Cat.-No.: AP20661PU-N) at 1/500 dilution Lane 1:HEK293T whole cell lysate Lane 2:NIH-3T3 whole cell lysate Lane 3:PC12 whole cell lysate

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western blot: 1/500-1/1000.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to amino acids 21-70 of Human CD3-δ
• Specificity: This antibody detects endogenous levels of CD3-δ protein.
  (region surrounding Thr56)
• Formulation: Phosphate buffered saline (PBS), pH 7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Predicted Protein Size: ~ 24 kDa
• Gene Name: CD3d molecule
• Database Link:
  Entrez Gene 915 Human
  UniProt ID P04234
• Background: The CD3 complex mediates signal transduction. Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-B+NK+ SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
• Synonyms: CD3D, T3D

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway