Cytochrome p450 2C19 (CYP2C19) Rabbit Polyclonal Antibody

CAT#: AP20543PU-N

Cytochrome p450 2C19 (CYP2C19) rabbit polyclonal antibody, Aff - Purified

Product Images

Western blot analysis of CYP2C19 antibody (Cat.-No AP20543PU-N) in extracts from 293 cells.

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  Immunohistochemistry analysis of CYP2C19 antibody (Cat.-No AP20543PU-N) in paraffin-embedded human liver carcinoma tissue.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution:

  Western blot: 1/500-1/1000.
  Immunofluorescence: 1/50-1/200.
  Immunohistochemistry on Paraffin Sections: 1/50-1/200.

• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody detects endogenous levels of CYP2C19 protein.
  (region surrounding Lys270)
• Formulation: PBS, pH~7.2
  State: Aff - Purified
  State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
  Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography using epitope-specific immunogen
• Conjugation: Unconjugated
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Predicted Protein Size: ~ 56 kDa
• Gene Name: cytochrome P450 family 2 subfamily C member 19
• Database Link:
  Entrez Gene 1557 Human
  UniProt ID P33261
• Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
• Synonyms: Cytochrome P450 2C19, CYPIIC17, CYPIIC19, Cytochrome P450-254C

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Linoleic acid metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism